PGT - SR

Unveiling the Potential

PGT-SR (Preimplantation Genetic Testing for Chromosomal Structural Rearrangements) offers a ray of hope for individuals who have a chromosome structural rearrangement, commonly known as a translocation. This advanced genetic testing procedure is specifically designed to enhance the likelihood of achieving a healthy pregnancy.

Chromosome rearrangements

Chromosomal rearrangements refer to alterations in the size or arrangement of chromosomes, the crucial structures that contain our genetic material. Individuals with such rearrangements face an elevated risk of producing embryos with an abnormal amount of genetic material, which commonly results in unsuccessful pregnancies.

  • segments of two chromosomes break off and change places

  • a segment of a chromosome has reversed orientation

  • a segment of a chromosome is missing

  • there is an extra segment of a chromosome

  • a segment of a chromosome has been inserted into the incorrect location

THE PROS & CONS

    1. Increased Pregnancy Success: PGT-SR enables the identification and selection of embryos with normal chromosomal structure, thereby enhancing the chances of successful implantation and healthy pregnancy.

    2. Reduced Risk of Miscarriage: Structural rearrangements in chromosomes often contribute to pregnancy loss. PGT-SR allows for the identification and transfer of embryos with normal chromosomal structure, reducing the risk of miscarriage.

    3. Minimized Transmission of Genetic Disorders: PGT-SR assists couples with known structural rearrangements in preventing the transmission of genetic abnormalities to their offspring.

    1. False Negative or Positive Results: As with any genetic testing method, there is a small possibility of obtaining false-negative or false-positive results during PGT-SR, which may impact the selection of embryos for transfer.

    2. Limited Scope: PGT-SR focuses specifically on detecting structural rearrangements in chromosomes and does not provide comprehensive screening for other genetic conditions or chromosomal abnormalities.

    3. Technical Challenges: PGT-SR can be technically complex and may require additional time and expertise to perform the necessary analyses accurately.

The Process

  • PGT-SR is typically carried out in conjunction with in vitro fertilization (IVF) treatment. The woman undergoes ovarian stimulation to produce multiple eggs, which are then retrieved for fertilization.

  • The retrieved eggs are fertilized with the partner's or a donor's sperm, resulting in the formation of embryos.

  • A small number of cells are carefully removed from each embryo to analyze the chromosomal structure and identify any structural rearrangements.

  • The extracted cells undergo comprehensive genetic analysis to assess the presence or absence of structural rearrangements.

  • Only embryos with normal chromosomal structure are selected for transfer into the woman's uterus, increasing the likelihood of successful implantation and a healthy pregnancy.

  • PGT-SR is highly accurate when performed by skilled professionals, but there is a small margin of error associated with the genetic testing process.

  • PGT-SR is designed to detect specific structural rearrangements in chromosomes. It may not identify other types of genetic abnormalities or chromosomal disorders.

  • Embryo biopsy is a delicate procedure, but in the hands of experienced specialists the risk of harm to the embryo is minimal.

PGT-SR offers a promising solution for couples with structural rearrangements in their chromosomes, helping them increase their chances of successful pregnancy while minimizing the risk of miscarriage and the transmission of genetic disorders. Understanding the benefits, risks, and procedural aspects of PGT-SR is crucial for individuals or couples considering this advanced reproductive technology. Seeking guidance from a specialized fertility clinic such as Fertility Athens, with the support from genetic counselor will provide personalized support and expertise throughout the process.

Book your non-obligatory discovery call today to see if we can help you make informed decisions and maximize your chances in realizing your dream of having a healthy family.